Amoxicillin is an extended spectrum aminopenicillin antimicrobial agent, most efficiently used in eradication of Helicobacter pylori. The present investigation is concerned with the development of the Gastro retentive floating tablets, containing amoxicillin, which after oral administration were designed to prolong the gastric residence time and thus to obtain better eradication rate and also to minimize the incident of bacterial resistance as well as side effects. Various formulations were developed by using Guar-gum as natural hydrocolloid; HPMC as a release rate controlling and gel forming polymer; Sodium bi-carbonate as gas generating agent. The air-pockets formed by effervescent of Sodium bi-carbonate within the floating system and natural hydrocolloid provided low density which lead to excellent in-vitro floating behavior of the tablets. All the formulations had floating lag time below 2 minutes and constantly floated on dissolution medium for more than 12 hours. From among all the developed formulations, as F3 prolonged the drug release for longer period of time, they were nominated as best formulations. Thus, best formulations satisfied physico-chemical parameters, floating time and in vitro drug release profile requirements for a floating drug delivery system.
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